Clarity (SPE) 样品制备信息

ClarityOTX™ 萃取试剂盒

从生物样品中快速分离寡核苷酸药物

典型萃取回收率大于 80 %
无需液液萃取 (LLE)
适用于大多数治疗性寡核苷酸、组织和体液

ClarityQSP™ 小柱和 96-孔板

高通量 RPC 纯化

RNA 和 DNA 的典型纯度和回收率都大于 90 %
适用于 10 - 100mer 的寡核苷酸
通过 3 个简单步骤分离三苯甲基保护寡核苷酸

ClarityRP-Desalting™ 小柱和 96 孔板

快速、简单地去除盐和试剂

去除盐和过量试剂，实现 70% 的典型纯度
获得目标寡核苷酸 80% 的典型回收率
用于净化脱三苯甲基的 DNA 和 RNA 序列

<div style=" float:left; width:50%">
<h2 style="cursor: auto"><strong style="cursor: auto">ClarityOTX™ 萃取试剂盒</strong></h2>

<p style="cursor: auto">从生物样品中快速分离寡核苷酸药物</p>

<ul style="cursor: auto">
	<li>典型萃取回收率大于 80 %</li>
	<li>无需液液萃取 (LLE)</li>
	<li>适用于大多数治疗性寡核苷酸、组织和体液</li>
</ul>
</div>

<div style=" float:left; width:50%">
<h2 style="cursor: auto"><strong style="cursor: auto">ClarityQSP™ 小柱和 96-孔板</strong></h2>

<ul style="cursor: auto">
	<li>RNA 和 DNA 的典型纯度和回收率都大于 90 %</li>
	<li>适用于 10 - 100mer 的寡核苷酸</li>
	<li>通过 3 个简单步骤分离三苯甲基保护寡核苷酸</li>
</ul>
</div>

<div style=" float:left; width:50%">
<h2 style="cursor: auto"><strong style="cursor: auto">ClarityRP-Desalting™ 小柱和 96 孔板</strong></h2>

<p style="cursor: auto">快速、简单地去除盐和试剂</p>

<ul style="cursor: auto">
	<li>去除盐和过量试剂，实现 70% 的典型纯度</li>
	<li>获得目标寡核苷酸 80% 的典型回收率</li>
	<li>用于净化脱三苯甲基的 DNA 和 RNA 序列</li>
</ul>
</div>

3 Phases

Reversed Phase 2

Ion-Exchange 1

Featured

BROCHURE

High-Throughput Synthetic DNA/RNA Purification

Developed to be a versatile, gentle, and extremely effective trityl-on purification process, Clarity QSP 96-well plates and cartridges deliver near impurity-free, concentrated full-length sequences.
BROCHURE

Extraction of Oligo Therapeutics from Biological Samples for LC/MS Bioanalysis

Clarity OTX is a simple, rapid, and reproducible solution that efficiently extracts oligos from biological matrices and can be easily automated.
TECHNICAL NOTE

Avoiding Depurination During Trityl-On Purification

Using Clarity QSP cartridges, we were able to substantially minimize if not eliminate depurination from occurring during purification.
TECHNICAL NOTE

Comparing Performance of High-Throughput, Trityl-On RNA/DNA Purification Products

Clarity QSP cartridges provide ease and efficacy not typically found in competing trityl-on purification platforms, such as the *TOP™ products.

QSP 固定相详细信息

QSP 固定相

High-Throughput Purification

Purify trityl-on synthetic DNA or RNA samples in 20 minutes using Clarity QSP™ 96-well plate and buffer system. Final elution delivers >90 % typical purities/recoveries for in vivo applications and downstream analysis by LC/MS or CE.

Formats offer easy high throughput processing for parallel purifications
Simple three-step process delivers highly purified DNA/RNA in minutes
For oligos 10-100 mer

2008 R&D 100 Award Recipient

Suitable for Most Oligo Therapeutics & Samples

Formats:	96-Well Plates and 3 mL Cartridges
Oligo Chemistry:	DNA & RNA
Synthesis Scale Load:	50 mg/well 96-well plates and 60mg/3mL tubes=up to 200 nmole 150 mg/ 3ml tubes= up to 1 µmole 5g/60mL tubes= up to 25 µmole
Oligo Length:	≤ 100 nt
Typical Purity¹:	≥ 90 %
Typical Recovery Yield²:	≥ 80 %
Purification Time:	~ 8 minutes/ cartridge ~ 45 minutes/ well plate (96 samples)
Equipment Required:	Positive pressure manifold, vacuum manifold, or automated liquid handling system

¹ Purity value based on ion exchange chromatography and capillary electrophoresis

²OD260 used for quantitation

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<div id="clarity-qsp">
<h3>High-Throughput Purification</h3>

<p>Purify trityl-on synthetic DNA or RNA samples in 20 minutes using Clarity QSP™ 96-well plate and buffer system. Final elution delivers >90 % typical purities/recoveries for in vivo applications and downstream analysis by LC/MS or CE.</p>

<ul>
	<li>Formats offer easy high throughput processing for parallel purifications</li>
	<li>Simple three-step process delivers highly purified DNA/RNA in minutes</li>
	<li>For oligos 10-100 mer</li>
</ul>

<div class="rdfigure">
<figure><img alt="R&D 100 Logo" src="https://www.phenomenex.com/webimage/rd100-logo.png" /> <figcaption style="margin-left: 21px">2008 R&D 100 Award Recipient</figcaption></figure>
</div>

<div class="qsprow" style="margin-top: -26px">
<h4>Suitable for Most Oligo Therapeutics & Samples</h4>

<table class="clarity-qsp">
	<tbody>
		<tr>
			<td><strong>Formats:</strong></td>
			<td>96-Well Plates and 3 mL Cartridges</td>
		</tr>
		<tr>
			<td><strong>Oligo Chemistry:</strong></td>
			<td>DNA & RNA</td>
		</tr>
		<tr>
			<td><strong>Synthesis Scale Load:</strong></td>
			<td style="padding-right: 7px">
			<ul>
				<li>50 mg/well 96-well plates and 60mg/3mL tubes=up to 200 nmole</li>
				<li>150 mg/ 3ml tubes= up to 1 µmole</li>
				<li>5g/60mL tubes= up to 25 µmole</li>
			</ul>
			</td>
		</tr>
		<tr>
			<td><strong>Oligo Length:</strong></td>
			<td>≤ 100 nt</td>
		</tr>
		<tr>
			<td><strong>Typical Purity<sup>1</sup>:</strong></td>
			<td>≥ 90 %</td>
		</tr>
		<tr>
			<td><strong>Typical Recovery Yield<sup>2</sup>:</strong></td>
			<td>≥ 80 %</td>
		</tr>
		<tr>
			<td><strong>Purification Time:</strong></td>
			<td>~ 8 minutes/ cartridge<br />
			~ 45 minutes/ well plate (96 samples)</td>
		</tr>
		<tr>
			<td><strong>Equipment Required:</strong></td>
			<td style="padding-right: 7px">Positive pressure manifold, vacuum manifold, or automated liquid handling system</td>
		</tr>
	</tbody>
</table>

<div>
<p style="margin-top: 2px"><sup>1</sup> Purity value based on ion exchange chromatography and capillary electrophoresis</p>

<p style="margin-top: -3px"><sup>2</sup>OD260 used for quantitation</p>
</div>
</div>

3 Phases

Reversed Phase 2

Ion-Exchange 1

文档类型:

文件类型	标题
手册	2022/2023 色谱产品指南 (Catalog)	加入我的文档
技术笔记	Automated Method Development of Oligonucleotide in Tissues Using Clarity OTX 96-Well Plate and High Resolution Mass Spectrometry (TN-0097)	加入我的文档
手册	Clarity Biosolutions for Synthetic DNA/RNA	加入我的文档
手册	Clarity QSP	加入我的文档
手册	生物制剂分析解决方案	加入我的文档
手册	生物制药解决方案色谱柱选择参照表	加入我的文档
技术笔记	Avoiding Depurination During Trityl-on Purification (TN-0008)	加入我的文档
手册	Clarity OTX	加入我的文档
支持文件	Clarity OTX User’s Guide	加入我的文档
支持文件	Clarity QSP User’s Guide (DNA)	加入我的文档
支持文件	Clarity QSP User’s Guide (RNA)	加入我的文档
技术笔记	Trityl-on RNA and DNA Purification (TN-0009)	加入我的文档
技术笔记	Oligonucleotide Therapeutics from Biological Matrices (TN-0048)	加入我的文档
支持文件	Collection Plate and Sealing Mat Selection Guide	加入我的文档
Other	Protein and Peptide Users Guide	加入我的文档
技术笔记	RNA Sample Preparation and High Throughput Purification for TBDMS and TOM Chemistries (TN-0016)	加入我的文档
支持文件	SPE 10, 12, and 24 Position Vacuum Manifold Instructions	加入我的文档
支持文件	SPE 96-Well Vacuum Manifold	加入我的文档

固定相: 吸附剂质量:

货号:8E-S102-DGS

描述:Clarity® 30 µm QSP, 50 mg / well, 96-Well Plates , 40/Pk

吸附剂类型:Polymer-based

格式:96-Well Plate

固定相:DVB

目标分析物:Oligos 10 – 100 mer

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货号	品牌	固定相	吸附剂质量 /体积	格式	价格

Oligonucleotide

Purification Products

Clarity (SPE) 样品制备信息

ClarityOTX™ 萃取试剂盒

ClarityQSP™ 小柱和 96-孔板

ClarityRP-Desalting™ 小柱和 96 孔板

Featured

High-Throughput Synthetic DNA/RNA Purification

Extraction of Oligo Therapeutics from Biological Samples for LC/MS Bioanalysis

Avoiding Depurination During Trityl-On Purification

Comparing Performance of High-Throughput, Trityl-On RNA/DNA Purification Products

QSP 固定相详细信息

QSP 固定相

High-Throughput Purification

Suitable for Most Oligo Therapeutics & Samples