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A paramagnetic particle, ideal for isolating proteins and peptides in less time with a high response. With a unique magnetic bead particle and rigorous specifications, bioZen MagBeads are created to ensure uniform beads that provide consistent and reliable results. View Products
Solid phase extraction (SPE) HILIC stationary phase that excels at retention and recovery labeled released N-glycans! Microelution format allows for streamlined processing and clean-up of small sample volumes. View Applications
With a new titanium hardware to minimize priming, three particle platforms for optimal versatility and eight particle chemistries to maximize selectivity and sensitivity, bioZen UHPLC/HPLC columns are seamlessly designed to bring peace of mind to your
Quantitation of aggregate is a critical quality attribute in biopharmaceutical development. The determination of monomer, dimer, and multimer, as well as higher order structure (quaternary structural determination of a mAb), and high/low molecular weight species are commonly observed through size exclusion chromatography.
The average drug-to-antibody ratio (DAR) is critical to assess in the development of antibody-drug conjugates (ADCs). Though different chromatography modes can be employed to determine DAR, a highly effective method utilized reversed phase chromatography.
Glycosylation of proteins-specifically monoclonal antibodies-have indications on protein structure and is arguably the most critical post-translational modification to characterize in biopharmaceutical development. N-glycan analysis through hydrophilic interaction chromatography (HILIC) is a robust method for absolute quantitation of glycoforms and is the gold standard for glycosylation characterization.
Intact mass analysis involves using high resolution accurate mass (HRAM) instrumentation to confirm protein sequence and identify post-translational modifications. Often in combination with reversed phase chromatography, intact mass analysis is utilized on native proteins, mAbs, and ADCs in biopharmaceutical development.
Observation of intact protein and fragmented protein during impurity profiling is essential in biologic development. Utilizing reversed phase chromatography on native protein and partially fragmented protein scientists can observe characteristics including heavy chain/light chain, Fc/Fab, or isoforms.
For protein characterization, peptide mapping is commonly used for identification of non-enzymatic, spontaneous post translational modifications, such as deamidation, oxidation, succinimide formation, pyroglutamate formation, and others. Reversed phase chromatography is used for confirming primary sequence, but is more commonly for PTM identification.
The determination of signature peptide concentration from biological matrices using LC-MS. Scientists utilize peptide quantitation to deconvolute complex chromatograms by searching for specific peptide sequences, which can analyze the peptides with high sensitivity and specificity, even at low levels of peptide.
Separate MABs from from acidic/basic variants .
Complex large molecules composed of amino acid polymer chains. Proteins in biopharmaceuticals typically range from 3,000-150,000 kDa. Under the biologics classification, biopharmaceutical proteins can be hormones, human growth factors, and monoclonal antibodies (mAbs). The most common biopharmaceutical proteins are insulin and mAbs.
A biologic with the same sequence and similar function to an innovator biologic. The characterization of biosimilars requires the same chromatographic techniques as its corresponding innovator biologic
Find you sample preparation state of zen. Isolate proteins and peptides in less time with higher response by utilizing uniform and reliable magnetic beads.
Peptide Quantitation with a bioZen Peptide PS C18 Column Following Antibody Enrichment Through Ligand Binding with bioZen MagBeads
Quantitation of Neutral and Sialylated Glycans using bioZen HILIC Chromatography and Solid Phase Extraction
With a unique magnetic bead particle and rigorous specifications, bioZen™ MagBeads are created to ensure accurate binding of targets proteins. Uniform beads make it easier than ever to ensure consistency and reliability. To help achieve the desired assay linear dynamic range, bioZen MagBeads were utilized and display high sensitivity and reproducibility with low variation between samples and batches to be a guaranteed replacement in current immunocapture methods.
货号:KS0-9533
描述:bioZen MagBeads, Streptavidin Coated - 500mg, Ea
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固定相:Proprietary
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