Avoiding Depurination During Trityl-on Purification (TN-0008)

Abstract:

Trityl-on methodologies for the analysis of crude synthetic oligonucleotides has many benefits however depurination during trityl-on methodologies can lead to nucleic acid damage. This technical note explores a new trityl-on procedure that minimizes the risk of depurination.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

Sample Prep

Brands:

Clarity (SPE) Clarity

PDF Link:

Click here