Comparison of UHPLC Particles for Intact Mass Subunit Analysis of Monoclonal Antibodies

Abstract:

The use of steep gradient slopes limits the separation when analyzing mAb subunits by intact mass. High efficiency particles could be adequate for this separation but the use of bioZen 2.6 µm WidePore C4 core-shell superficially porous particles may be optimal in instances where efficiency is required for detection and separation of low level impurities.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

bioZen

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