Effect of Flow Rate on Reversed Phase Separations of Monoclonal Antibodies
- Abstract:
- The analysis of intact monoclonal antibodies (mAbs) by reversed phase HPLC is a common technique for assessing protein variation, such as clipping and heterogeneity due to post-translational modifications. Whether for LC-UV impurity analysis or for confirming primary sequence using LC-MS, the analysis of intact mAbs can provide useful insight on a protein therapeutic.
- Document Type:
- Technical Notes
- Industries:
- Pharmaceutical/Biopharmaceutical
- Techniques:
- HPLC / UHPLC
- Brands:
- bioZen
- PDF Link:
- Click here