Extraction and Analysis of Fentanyl and Analogs from Whole Blood

Abstract:

Fentanyl and fentanyl analogs are high potency synthetic opioids that are 80-100x more powerful than morphine. Although fentanyl use is strictly regulated, new fentanyl analogs keep emerging with molecular structures that are closely related, making separation, identification, and quantitation difficult for analysts. This method explores the identification of 26 compounds and quantitation of 24 compounds using multiple sample preparation techniques to clean-up the whole blood matrix. A core-shell LC column was utilized for its high efficiency and selective properties and the F5 phase was chosen for separating geometric and structural isomers.

Document Type:

Technical Notes

Industries:

Clinical

Techniques:

HPLC / UHPLC

Brands:

Kinetex Strata

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