Compendial Methods: Determination of Impurities and Related Substances (TN-1069)

Abstract:

Recently, a newly developed Kinetex™ 2.6 μm core-shell chromatographic particle has been commercialized that offers the performance benefits of sub-2 μm fully-porous particles but at substantially lower operating pressures. To demonstrate the performance benefits of this new core-shell technology, a Kinetex™ 2.6 μm core-shell C18 column was compared with a fully porous 5 μm C18 column referenced in EP ([Ph. Eur.] European Pharmacopoeia) Monograph 0703 for Atenolol and related substances on a conventional HPLC instrument with an upper pressure limit of 400 bar

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Kinetex

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