Optimization of Chromatography for Intact Mass Analysis of Monoclonal Antibodies

Abstract:

temperature and gradient slope are two critical method parameters to investigate for intact mass applications for mAbs. In addition, gradient slope can be optimized by changes in gradient program (i.e. gradient start/end, program length) as well as flow-rate.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

bioZen

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