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Luna HPLC Information


NEWLuna Omega C18 (1.6 μm, 3 μm, 5 μm)

  • Exciting Reproducibility Through New PEAK Process
  • Fully Scalable Selectivity UHPLC to HPLC to PREP
  • The USP L1 Column to Start Methods With
  • High durability and mechanical strength
 
 
Ω

The Technology Behind Luna Omega

Enhanced with 20 Years of technology, innovation, and experience, Luna Omega columns build upon the Luna legacy to now provide incredible HPLC/UHPLC performance and selectivity. With Luna Omega columns you gain:

  • Greater separation muscle
  • Better peak shape through an inert foundation
  • Extreme ruggedness and dependability

Thermal Modified Pore Structure

Elimination of micropores, further improves column efficiency, inertness, and reproducibility.

Micropores
Absence of
Micropores
Consistent
Porosity
1

Luna Omega C18

Rugged C18 with focus on strong hydrophobic retention of non-polar and polar compounds.

Particle Size (µm): ID (mm):
1.6 1.0 (Microbore)
2.1 (Minibore)
3 2.1 (Minibore)
3.0 (MidBore)
4.6 (Analytical)
5 2.1 (Minibore)
3.0 (MidBore)
4.6 (Analytical)
21.2 (Prep
2

Luna Omega Polar C18

100 % aqueous stability and enhanced selectivity/retention for polar analytes without diminishing useful non-polar retention

Particle Size (µm): ID (mm):
1.6 1.0 (Microbore)
2.1 (Minibore)
 
3 0.3 (Micro Flow)
0.5 (Micro Flow)
2.1 (Minibore)
3.0 (MidBore™)
4.6 (Analytical)
 
5 0.3 (Micro Flow)
0.5 (Micro Flow)
2.1 (Minibore)
3.0 (MidBore™)
4.6 (Analytical)
10 (Semi-Prep)
21.2-50 (Prep)
3

Luna Omega PS C18

Unique mixed-mode selectivity with enhanced retention for polar acids, better peak shape for bases and 100% aqueous stability

Particle Size (µm): ID (mm):
1.6 1.0 (Microbore)
2.1 (Minibore)
 
3 0.3 (Micro Flow)
0.5 (Micro Flow) 2.1 (Minibore)
3.0 (MidBore™)
4.6 (Analytical)
 
5 0.3 (Micro Flow)
0.5 (Micro Flow)
2.1 (Minibore)
3.0 (MidBore™)
4.6 (Analytical)
10 (Semi-Prep)
21.2-50 (Prep)
 

See the Technology in Action

Download the Luna product guide and view applications, method development tips and for optimizing separations with Luna Omega UHPLC.HPLC columns.

Download Now »
 
 

Luna HPLC and PREP

As one of the world’s most recognized HPLC brands, Luna is a high quality, industry standard that is incredibly dependable, batch to batch and column to column. With a highly versatile family of selectivities, Luna stationary phases will help drive your method development and leave you at ease with existing methods.

Phase Description Application
Silica(2) Unbonded silica Non-polar compounds
C5 5 Carbon ligand Good alternative to C8 when less retention is desired
C8(2) C8 ligand optimized for improved peak shape Great starting phase for method development
C18(2) C18 ligand optimized for improved peak shape From capillary LC/MS to process scale Our most popular phase
CN Versatile CN phase For improving the retention of polar compounds
NH2 Rugged and reproducible NH Sugar alcohols, anionic or hydrogen bonding compounds
Phenyl-Hexyl Phenyl phase attached to C6 (hexyl) ligand Unique selectivity for very polar and aromatic compounds
SCX Benzene sulfonic acid Amine and polyamine containing compounds
HILIC Reproducible, cross-linked diol Increased retention and MS sensitivity of polar compounds
PFP(2) Pentafluorophenyl with a C3 (propyl) linkage Highly polar compounds, halogenated compounds and isomers

C18(2)


Particle Sizes (µm)2.5, 3, 5, 10, 15
Pore Size (Å)100
Surface Area (sq. m/g)400
Carbon Load (%)17.5
Compare All Phases

C18(2) Phase Information


Optimized Peak Asymmetry and Selectivity

Luna C18(2) phase is an octadecyl silane with ligands bound to the silica surface,resulting in a C18 HPLC column with very hydrophobic stationary phase that offers great methylene selectivity. The non-polar endcapping of the Luna C18(2) column phase virtually eliminates silanol interactions resulting in a reversed phase HPLC column that can be used for USP methods or general LC method development.

Phase
Description
Slightly lower carbon load than original Luna C18
USP
Classification
L1:Octadecyl silane chemically bonded to porous or non-porous silica or ceramic micro-particles, 1.5 to 10 µm in diameter
Trending
Applications
Luna C18(2) Peal Asymmetry Chromatogram

Popular Part Numbers

Part Number Particle Size (µm) Pore Size (Å) Length (mm) I.D. (mm)
00G-4252-E0 5 µm 100 Å 250 4.6
00F-4252-E0 5 µm 100 Å 150 4.6
00F-4251-E0 3 µm 100 Å 150 4.6
00F-4251-E0 3 µm 100 Å 100 4.6
View all Luna HPLC* column part numbers »

*Luna C18 (2) is a recommended alternative to: Agilent Technologies® ZORBAX® SB-C18, Waters Symmetry® C18, Sigma-Aldrich Biotechnology Supelcosil™ ABZ and GL Sciences Inertsil® ODS (2).

Agilent Technologies and ZORBAX are registered trademarks of Agilent Technologies, Inc. Inertsil is a registered trademark of GL Sciences. Supelcosil is a trademark of Sigma-Aldrich Co, LLC. Waters, and Symmetry are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Agilent Technologies, GL Sciences, Sigma-Aldrich, or Waters Corporation.

C18(2) LC Column Care & Use

  • Column Flow Rate and Backpressure
  • Column Installation
  • Mobile Phase Compatibility
  • Shipping Solvent
Download Now »
PhaseParticle Sizes (µm)Pore Size (Å)Surface Area (sq. m/g)Carbon Load (%)Recommended Use
C183, 5, 1010044019Separation of hydrophobic compounds
C18(2)2.5, 3, 5, 10, 1510040017.5Separation of hydrophobic compounds
C55, 1010044012.5Separation of extremely hydrophobic compounds
C83, 5, 1010044014.75Separation of very hydrophobic compounds
C8(2)3, 5, 10, 1510040013.5Separation of very hydrophobic compounds
CN3, 5, 101004007Separation of polar compounds
HILIC3, 5200200*5.7Separation of polar compounds
NH23, 5, 101004009.5Separation of polar compounds
Omega C181.6, 3, 510026011.0
Omega Polar C181.6, 3, 510026011.0
Omega PS C181.6, 3, 510026011.0
Omega SUGAR3100N/A
PFP(2)3, 5100400N/ASeparation of aromatic and halogenated compounds
Phenyl-Hexyl3, 5, 10, 1510040017.5Separation of aromatic compounds
Polar Pesticides3100N/A
PREP C18(2)10100N/A
PREP C18(3)10100N/A
PREP C410100N/A
PREP C8(2)10100N/A
PREP C8(3)10100N/A
PREP Phenyl-Hexyl10100N/A
PREP Silica(2)10100N/A
PREP Silica(3)10100N/A
SCX5, 101004000.55 % Sulfur LoadSeparation of positively charged compounds
Silica (2)3, 5, 10, 15100400N/ASeparation of polar compounds
Document Type:
Document Type Title
Brochures 2022/2023 色谱产品指南 (Catalog) Add to My Documents
Brochures 6 Reasons to Try Luna Omega Instead of ACQUITY® BEH Add to My Documents
Technical Notes A Single Column and Mobile Phase Workflow for LC-MS/MS Analysis of a Comprehensive Drug Research Panel and Ethanol Metabolites (TN-1227) Add to My Documents
Technical Notes Amlodipine Besylate USP Monograph Add to My Documents
Technical Notes Analysis and Quantitation of Pre-Workout Powder Components in Matrix by LC/UV using Luna® 3 μm HILIC HPLC Column (TN-1207) Add to My Documents
Technical Notes Analysis of Desmopressin from Human Plasma using Strata-X-CW and a Luna Omega Polar C18 Column Add to My Documents
Technical Notes Atenolol Ph. Eur Monograph Add to My Documents
Brochures Axia- The Ultimate Pre-packed Preparative Column Add to My Documents
Technical Notes LC/MS/MS Analysis of Underivitized Methylmalonic Acid (MMA) and Succinic Acid in Plasma Using Strata-X-AW and Luna Omega 1.6 μm PS C18 Add to My Documents
Brochures Cannabis Testing Guide Add to My Documents
Brochures Capillary and Trap Column Solutions for Microflow LC Add to My Documents
Technical Notes Clavulanate Potassium USP Monograph Add to My Documents
Other Clinical Research Solutions Guide Add to My Documents
Brochures Custom Method Development and Optimization Services for Clinical Research Add to My Documents
Technical Notes Optimization Tips for HILIC Analysis of Basic Compounds (TN-1040) Add to My Documents
Technical Notes Determination of Cylindrospermopsin and Anatoxin-a in Drinking Water by UHPLC/MS/MS using a Luna® Omega 1.6 μm Polar C18 (EPA Method 545) Add to My Documents
Technical Notes Determination of Microcystins and Nodularin in Drinking Water by UHPLC/MS/MS using a Luna Omega 1.6 μm Polar C18 (EPA Method 544) Add to My Documents
Technical Notes Determination of Pantothenic Acid (Vitamin B5) in Human Serum by LC-MS/MS using a Luna Omega Polar C18 column Add to My Documents
Technical Notes Determination of Perfluoroalkyl Substances (PFAS) in Sediments by QuEChERS and LC-MS/MS (TN-0117) Add to My Documents
Technical Notes Determination of Pesticide Residues in Cannabis by LC-MS/MS (TN-1224) Add to My Documents
Technical Notes Determination of Tricyclic Antidepressants (TCAs) from Urine using Luna Omega and Kinetex Polar C18 Columns Add to My Documents
Technical Notes Determination of Vitamin B2 and B3 in Human Serum by LC-MS/MS using a Luna Omega Polar C18 Column Add to My Documents
Other Drugs and Metabolites Guide Add to My Documents
Brochures Explore Luna HPLC Columns Add to My Documents
Brochures Extend your Analytical and Preparative HPLC/ SFC Column Lifetimes Add to My Documents
Technical Notes Extraction and Analysis of Plasma Catecholamines and Metanephrines (PMETs) Using Strata-X-CW Microelution SPE and a Luna Omega Polar C18 LC Column Add to My Documents
Technical Notes Extraction and Analysis of Urinary Catecholamines by LC-MS/MS Using Strata-X-CW Microelution Solid Phase Extraction and Luna Omega and Kinetex Polar C18 LC Columns Add to My Documents
Technical Notes Extraction and Analysis of Vitamin B1 (Thiamine) from Guar Gum by HPLC-UV (TN-1223) Add to My Documents
Technical Notes Fast and Simple Analysis of Polyphenols in Red Wine (TN-1166) Add to My Documents
Technical Notes Fluconazole Ph. Eur Monograph Add to My Documents
Technical Notes Fluoxetine Hydrochloride Ph. Eur Monograph Add to My Documents
Technical Notes Fluticasone Propionate USP Monograph Add to My Documents
Technical Notes Glyphosate Analysis by LC/MS/MS using FMOC Derivitization or Underivitized Method Add to My Documents
Other HPLC/UHPLC Column Phase Selection Chart Add to My Documents
Brochures Improve Your Bioanalytical Assays Today Add to My Documents
Technical Notes Increasing LC-MS MS Sensitivity with Luna HILIC Add to My Documents
Brochures Kinetex and Luna Omega : Combined Performance and Selectivity Gains for HPLC/UHPLC Add to My Documents
Technical Notes LC-MS/MS analysis of 23 Synthetic Cathinones (Bath Salts) from Urine using Luna® Omega 3 μm Polar C18 Add to My Documents
Technical Notes LC/MS/MS Analysis of Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) from Urine Using a Luna Omega 1.6 μm UHPLC Column (TN-1201) Add to My Documents
Technical Notes Lovastatin USP Monograph Add to My Documents
Brochures Luna Omega Brochure Add to My Documents
Technical Notes Metformin Hydrochloride USP Monograph Add to My Documents
Technical Notes Metoprolol Tartrate Ph. Eur Monograph Add to My Documents
Technical Notes Optimization of the USP HPLC Methodology for Boswellia serrata with Advancements in HPLC/UHPLC Column Chemistry TN-1232 Add to My Documents
Technical Notes Oxycodone Hydrochloride Ph. Eur Monograph Add to My Documents
Technical Notes Paroxetine Hydrochloride Ph. Eur Monograph Add to My Documents
Technical Notes Per-Fluoroalkyl Substances (PFAS) from Butter using roQ™ QuEChERS and Strata-X-AW Solid Phase Extraction by LC-MS/MS Add to My Documents
Brochures Pesticide Analysis by GC/LC/Sample Prep Add to My Documents
Technical Notes PFAS Analysis in Water Samples using LC/MS/MS Large-Volume Direct Injection Add to My Documents
Technical Notes PFAS from Milk, Eggs, Butter, Cheese, and Fish using QuEChERS, SPE, and LC-MS/MS Add to My Documents
Other Pharmaceutical Analysis Guide- Formulations Add to My Documents
Technical Notes Pravastatin Sodium Ph. Eur Monograph Add to My Documents
Technical Notes Pravastatin Sodium USP Monograph Add to My Documents
Technical Notes Rapid Analysis of 125 pesticides from Ground Water by UHPLC-MSMS using Luna Omega 1.6 µm C18 Add to My Documents
Technical Notes Rapid Analysis of 23 Per- and Poly-Fluorinated Alkyl Substances (PFASs) by UHPLC-MS/MS using Luna Omega 1.6 μm PS C18 Add to My Documents
Technical Notes Reversed Phase HPLC Separation of Sulfa Drugs on a Luna Omega 3 μm Polar C18 Column Add to My Documents
Brochures SecurityGuard Column Protection Family Brochure (UHPLC, HPLC, PREP, SFC) Add to My Documents
Technical Notes Separation of Twelve Major Cannabinoids using a Luna Omega Polar C18 in Two Particle Sizes: 3 μm and 5 μm Add to My Documents
Technical Notes Tech Note Add to My Documents
Other THE Clinical Application Notebook, Volume 1 Add to My Documents
Other The Comprehensive Guide to HPLC/UHPLC Reversed Phase Selectivity Add to My Documents
Technical Notes TN-1218: The Impact of Sample Solvent Composition and Injection Volume on Chromatographic Performance and Loading Add to My Documents
Brochures Toxicology Greatest Hits featuring Sample Preparation and LC Add to My Documents
Technical Notes Tramadol Hydrochloride Ph. Eur Monograph Add to My Documents
Technical Notes Trimethoprim USP Monograph Add to My Documents
Technical Notes Two New Approaches to Analyzing EtS / EtG from Urine (TN-1209) Add to My Documents
Other Ultimate Guide to Reversed Phase HPLC/UHPLC - Column Selectivity Selection Poster Add to My Documents
Other USP and EP Monograph Guide Add to My Documents
Technical Notes Vitamin A and E Analysis From Infant Formula Using Luna® 3 μm NH2 per AOAC OMA 2012.10 (TN-1190) Add to My Documents
Technical Notes A Selective Method for Quantitation of Underivatized Methylmalonic Acid (MMA) in Plasma Add to My Documents
Other A Simple, Rapid Method for teh Analysis of Ethephon from Ketchup using Solid Phase Extraction and LCMSMS Add to My Documents
Technical Notes Achiral Stationary Phase Selectivity under SFC Conditions (TN-1041) Add to My Documents
Technical Notes Analytical Approaches for the Identification and Quantitation of Organic Explosives by LC-HRMS Add to My Documents
Brochures Bulk Media Selection Guide Add to My Documents
Technical Notes Change Selectivity, Not the Stationary Phase, for Synthetic Peptide Multi-Step Purifications (TN-1177) Add to My Documents
Technical Notes Choosing the Right UHPLC Column for Analyzing Highly Lipophilic (Non-Polar) Molecules Add to My Documents
Technical Notes Choosing the Right UHPLC Column for Analyzing Highly Polar Acidic Molecules Add to My Documents
Technical Notes Choosing the Right UHPLC Column for Analyzing Strongly Basic Molecules Add to My Documents
Technical Notes Choosing the Right UHPLC Column for General Pharmaceutical Screening Add to My Documents
Technical Notes Choosing the Right UHPLC Column for Highly Polar Basic Compounds Add to My Documents
Technical Notes Choosing the Right UHPLC Column for Intact Peptide Analysis Add to My Documents
Technical Notes Choosing the Right UHPLC Column for Multi-Class LC-MS/MS Screening - Pesticides Panel Add to My Documents
Technical Notes Choosing the Right UHPLC Column for Peptide Mapping Add to My Documents
Technical Notes Glucosinolates from Cruciferous Vegetable Extracts by HPLC/UV (TN-1157) Add to My Documents
Supporting Docs Guidelines for HILIC Method Development Add to My Documents
Technical Notes LC-MS/MS Analysis of Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) in Urine using Luna Omega 5 μm Polar C18 HPLC Column Add to My Documents
Technical Notes LC/MS/MS Analysis of Homocysteine using Luna® Omega 1.6 μm PS C18 UHPLC Column Add to My Documents
Technical Notes LC/MS/MS Analysis of Mitragynine and 7-OH Mitragynine using Luna Omega 1.6 μm PS C18 UHPLC Column Add to My Documents
Technical Notes LC/MS/MS Analysis of Synthetic Cathinones (Bath Salts) from Urine and Whole Blood using a Luna® Omega 1.6 μm C18 UHPLC Column and Strata®-X-Drug B Solid Phase Extraction (SPE) Add to My Documents
Supporting Docs Luna 2.5 µm C18(2) HST White Paper Add to My Documents
Supporting Docs Luna and Luna Omega Care and Use Notes Add to My Documents
Technical Notes Oxytocin (OT) and ARG-Vasopressin (AVP) from Human Plasma by SPE and LC/MS Add to My Documents
Technical Notes Peptide Separations by Cation Exchange HPLC (TN-1024) Add to My Documents
Technical Notes Rapid Extraction and Analysis of Natural and Synthetic Cannabinoids from Human Urine (TN-0118) Add to My Documents
MSDS Safety Data Sheet for Silica-Based HPLC Columns Add to My Documents
Technical Notes Screening and Confirmation of Synthetic Cannabinoid Urinary Metabolites using Kinetex Core-Shell Columns and a Luna Fully Porous Column (TN-1179) Add to My Documents
Technical Notes Thiamin Diphosphate (Vitamin B1) from Whole Blood by LC-Fluorescence Add to My Documents
Other USP Allowable Adjustments Guide Add to My Documents
Technical Notes Vitamin B1 and B6 from Whole Blood Add to My Documents
Other Allowable Adjustments to European Pharmacopoeia (EP) Methods Add to My Documents
Technical Notes Development of a Multi-Step Purification Process for the Purification of Exenatide (TN-1203) Add to My Documents
Technical Notes LC-MS/MS Method of Phosphatidylethanol (PEth) in Whole Blood (TN-1222) Add to My Documents
Brochures Luna C18 (3) Add to My Documents
Supporting Docs Luna Column Selection by Ph. Eur. Listings and Tolerances Add to My Documents
Supporting Docs Meeting All Your PREP Needs Add to My Documents
Supporting Docs Meeting All Your SFC Needs Add to My Documents
Technical Notes Metformin HCL by HPLC per the USP Monograph Add to My Documents
Technical Notes Optimization of Preparative Production using Axia™ for Increased Purity, Yield and Productivity (TN-1049) Add to My Documents
Technical Notes Peptide Purification Method Development: Application for the Purification of Bivalirudin (TN-1129) Add to My Documents
Technical Notes Melamine from Food Products by SPE and LC/MS/MS (TN-0019) Add to My Documents
Technical Notes Free Metanephrine (MN) and Normetanephrine (NMN) from Plasma by SPE and LC/MS/MS (TN-0018) Add to My Documents
Brochures Preparative/Process Add to My Documents
Supporting Docs Axia Packed Columns Vs Traditional Packed Preparative Columns (Video) Add to My Documents
Supporting Docs HPLC Column Care Guide Add to My Documents
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