Sample Preparation

Featured SPE Products

Strata-X SPE Products

Strata-X Polymeric SPE Sorbents

  • Easily retain target analytes
  • Effectively remove contaminants
  • Cleanup and concentrate analytes
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Strata SPE Tubes and 96-Well plates

Strata SPE Sorbents

  • Wide selectivity
  • Clean extracts
  • High recoveries
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Recommended Accessories

Simple SPE Method Development

Develop an SPE Method in Under a Minute

Clean Up and Concentrate Analytes

A Quick Look at Solid Phase Extraction (SPE)

Solid phase extraction is an effective technique for cleaning up and concentrating samples, prior to HPLC or GC analysis. The technique offers targeted selectivity for analytes of interest, versatility for a wide range of sample volumes, can be easily automated for high-throughput, and is performed by following quick and simple methods ( load, wash, elute).

Solid Phase Extraction (SPE)

Featured Protein Precipitation Products

Impact Protein Precipitation Plates

Impact Protein Precipitation Plates

  • Fast, easy to follow protocol; clean 96 samples in under 15 minutes
  • No manual or automated filtrate transfer steps required
  • Automatable process for higher productivity
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Recommended Accessories

Easily Remove Proteins

A Quick Look at Protein Precipitation (PPT)

Proteins in biological sample matrices have a dramatic effect in HPLC/UHPLC column lifetime and can interfere with MS detector sensitivity. Protein precipitation is a simple sample preparation technique that is used to remove proteins from the sample using an organic solvent or a salt.


Although there are several methods for precipitating proteins from plasma and tissue, very few offer reproducible and effective removal of proteins from sample without excessive sample transfer, which can result in loss of recovery of the target analyte.

The ideal protein precipitation method allows for consistent protein removal with as few sample transfers as possible.

Protein Precipitation

Featured Phospoholipid Removal Products

Phree Phospholipid Removal Tube and Plates

Phree Phospoholipid Removal Products

  • Eliminate ion-suppression by removing phospholipids
  • Skip the method development; one method for acids, bases, and neutrals
  • Extend HPLC/UHPLC column lifetime by removing phospholipids
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Recommended Accessories

Easily Remove Phospholipids

A Quick Look at Phospholipid Removal (PLR)

Phospholipids have been shown to reduce HPLC/UHPLC column lifetime and sensitivity and are also responsible for ion suppression. Phospholipids are present in a majority of bioanalytical samples including whole blood and plasma. With an increasing number of clinical applications being developed from bioanalytical samples, the removal of phospholipids from the sample prior to LC/MS/MS analysis has become an important step for accurate analysis.

Protein Precipitation

Featured QuEChERS Products

roQ Quechers Kits

roQ QuEChERS Kits

  • Simplified and reproducible cleanup
  • No leaks, spills, or messes
  • Includes built in rack, easy pour packets, and leak free tubes
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Recommended Products

QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe)

A Quick Look at QuEChERS

QuEChERS (an acronym for Quick, Easy, Cheap, Effective, Rugged, and Safe) is a commonly used sample preparation technique that is employed in most multi-residue pesticide testing laboratories.In residue testing, the primary challenge is to eliminate naturally occurring pigments, fats, waxes, and other unwanted interferences from the sample matrix in order to achieve lower limits of detection and quantification of pesticides.


Traditional techniques using liquid/liquid extraction employed the use of hazardous solvents, and suffer from poor recoveries for polar pesticides.

The QuEChERS method has proved to be extremely versatile for simultaneous analysis of multiple classes of pesticides from various matrices. The large variety of food matrices, ranging from aqueous, fiber rich, to fat/oil based foods can undergo a relatively simple cleanup using different sorbent mixtures and a single technique.

Featured Filtration Products

Phenex Syringe Filters

Phenex Syringe Filters

  • Maximum chemical compatibility
  • Excellent flow rate
  • Low protein absorption
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Recommended Products

Find a Syringe Filter

Try the Syringe Filter Finder Tool

Remove Contaminants

A Quick Look at Filtration

In HPLC, particulates and microbial growth in mobile phase buffers and samples can damage expensive HPLC equipment such as pumps, valves, columns and detectors. They can also lead to erratic analytical results. Pre-filtering samples and mobile phases prior to analysis can help prevent column and frit blockage, abnormally high operating pressures, and can undue wear on valve and injector seals.

Syringe filters are commonly used to pre-filter samples with volumes ranging from 1-100 mL because they can easily attach to any syringe. The sample is pushed through the syringe filter membrane which traps particulates, resulting in a contaminant and particulate free sample.


Featured SLE Products

Novum SLE Tube and Plates

Strata DE Supported Liquid Extraction (SLE) Products

  • A guaranteed alternative to other Diatomaceous Earth SLE Products
  • A quick and easy method
  • Available for large volume formats
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Recommended Accessories

Easily Remove Contaminants

A Quick Look at Simplified Liquid Extraction (SLE)

SLE simplifies the liquid-liquid extraction product by eliminating the formation of emulsions and the need to manually separate liquid phases. Simply load your aqueous sample onto the solid support and allow it to soak into the sorbent. After 5 minutes, apply the same organic solvent that you would use for a liquid-liquid extraction. Target analytes will partition into the organic solvent and elute from the sorbent, leaving behind contaminants such as phospholipids, proteins, and salts

SLE Liquid Extracion (SLE)

Featured Products

Beta Gone SLE Tubes and 96-well Plates

β-Gone β-Glucuronidase Removal Products

  • Increase HPLC/UHPLC Column Lifetime
  • Reduce Mass Spec Maintenance
  • Maintain the Selectivity of Your HPLC/UHPLC Column
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Recommended Accessories

Presston 100 Positive Pressure Manifold

  • Uniform Flow Rate When Processing Samples
  • Utilizing a single manifold, 96-well plates, 1 mL, 3 mL, and 6 mL tubes can be used with a simple adaptor kit.


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